Research Associate, Biophysical Characterization

Company: Audentes Therapeutics, Inc.
Location: South San Francisco
Posted on: May 3, 2021

Job Description:

Why Work for Us

Are you ready to use your experience and expertise to make an impact on patients' lives? Audentes is a biotechnology company developing new genetic medicines for rare, life-threatening diseases. We are working urgently to progress our medicines and need additional team members to help us do so. Because our mission is so important, our values are to: Be BOLD: Find a Way, Care Deeply, and Get Stuff Done. If you'd like to be a part of this important mission, please apply to join our team.

About Audentes Therapeutics

Audentes Therapeutics, An Astellas Company, is developing genetic medicines for patients with rare, life-threatening diseases. Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Astellas Center of Excellence for their newly-created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach under Astellas. We are based in San Francisco, with manufacturing and laboratory facilities in South San Francisco and Sanford, North Carolina. For more information, please visit our website: www.audentestx.com

Our Values:

• Be BOLD (Find a Way)
• Care Deeply - for our patients, each other and our work
• #GSD (Get Stuff Done)

What is the catalyst for you in your professional career? Are you ready to be a part of a bold, innovative company, to make a change and to make a difference? Listed below is a current opening for a smart, driven, experienced, and just plain nice individual who wants to join us and be a part of our journey.

The Role

Reporting to the Principal Scientist, Analytical Development; the Research Associate's responsibilities will include performing analytical method development and testing samples using HPLC, capillary electrophoresis and other analytical tools; contributing to design and performing experiments with supervision as needed, for completing tasks within assigned time frames and for maintaining a well-documented record of activities in batch records and lab notebook. Additionally, the role includes regularly summarizing experiments in lab meetings and assisting in generating reports. This role will be at our South San Francisco location.

Primary Responsibilities

• Conducting experiments to characterize adeno associated viral nanoparticles for gene therapy products
• Developing and running assays for particle/protein/DNA characterization using chromatography (RP, SEC, IEC - HPLC methods)
• Developing additional assays as needed for process development and formulation studies
• Developing new characterization tools or following SOPs and running experiments according to guidelines
• Assisting in formulation and stability study set up, monitoring and analyzing data using statistical methods
• Assisting in writing, reviewing, and editing experimental procedures and reports
• Maintaining accurate records of all analytical development activities
• Analyzing and determining the applicability of laboratory data to draw conclusions and to make appropriate recommendations

About you

Must Have/Required

• Research Associate, I: Bachelor of Science with 1+ year experience; Research Associate, II: Bachelor of Science with 1-5+ years' experience or a Master's degree with 1+ year experience; Research Associate, III: Bachelor of Science with 5-8+ years' experience or a Master's degree with 3-5+ years'; Senior Research Associate, Bachelor of Science with 8+ years' experience or a Master's degree with 5+ years' experience working in a pharmaceutical or biotech company and with the requisite years' of experience and with the requisite years' of experience employing the skills listed in the job description (for each level) performing biophysical assays for the characterization of proteins
• Successful experience operating SE-HPLC & RP-HPLC (Waters preferred) for protein/DNA based product development including HPLC trouble-shooting
• Strong knowledge of Protein and DNA chemistry
• Knowledge and proven experience in protein based product development and characterization
• Knowledge and expertise in principles and practice of current Good Manufacturing Practices (cGMP)
• Knowledge of protein stability, degradation and aggregation testing
• Proficient in Microsoft Office to include Excel, PowerPoint, Word
• Demonstrated verbal and written skills in technical reports and documents
• Positive, professional self-starter with a passion for science
• Proven ability to work collaboratively in a team environment as well as being an individual contributor
• Models our Core Values: Be Bold: Find a Way, Care Deeply, Get Stuff Done - is experienced as someone who exemplifies the culture we want to create; operates with transparency; is trusted

May Have/Preferred

• Knowledge of protein formulation
• Experience with Waters platform
• Experience in analytical method development and validation

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.

Keywords: Audentes Therapeutics, Inc., South San Francisco , Research Associate, Biophysical Characterization, Other , South San Francisco, California