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Scientist. Physiological Chemistry

Company: Genentech
Location: South San Francisco
Posted on: May 3, 2021

Job Description:

The Department of Physiological Chemistry at Genentech is seeking a talented Scientist with a strong background in protein biochemistry and structural biology to characterize challenging membrane and soluble proteins that regulate cell death and inflammation. This Scientist will be responsible for the production of high-quality protein reagents and their biophysical and structural characterization. Proficiency in x-ray crystallography and/or cryo-EM methods is strongly desired.

A passion to explore the structural basis of protein-protein interactions is essential, as is a proven track-record of optimizing the expression and purification of proteins for functional and structural studies. Hands-on experience with soluble and membrane protein classes is highly desired.

The successful candidate will be a technical expert capable of leading from the bench or through collaborations with colleagues.

Required qualifications

Ph.D. in biochemistry, biophysics, protein engineering, and/or structural biology with experience on multiple challenging protein targets. Productive postdoctoral training and/or industry experience is expected and should be reflected in an established track-record of high impact publications.

Additional desired qualifications:

Hands-on experience engineering and optimizing the production of challenging protein targets for structural and/or functional studies.

Ability to generate and characterize milligram quantities of high-quality protein reagents.

Proficiency in structure determination using X-ray crystallography and/or cryo-EM is preferred.

Experience with protein engineering and/or design approaches.

Analysis, design, and/or computational approaches to investigate protein complexes.

Excellent communication, interpersonal, and organizational skills.

Team-oriented and collaborative with a fearless attitude to tackle important biological questions.

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Keywords: Genentech, South San Francisco , Scientist. Physiological Chemistry, Other , South San Francisco, California

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