The Department of Physiological Chemistry at Genentech is
seeking a talented Scientist with a strong background in protein
biochemistry and structural biology to characterize challenging
membrane and soluble proteins that regulate cell death and
inflammation. This Scientist will be responsible for the production
of high-quality protein reagents and their biophysical and
structural characterization. Proficiency in x-ray crystallography
and/or cryo-EM methods is strongly desired.
A passion to explore the structural basis of protein-protein
interactions is essential, as is a proven track-record of
optimizing the expression and purification of proteins for
functional and structural studies. Hands-on experience with soluble
and membrane protein classes is highly desired.
The successful candidate will be a technical expert capable of
leading from the bench or through collaborations with
Ph.D. in biochemistry, biophysics, protein engineering, and/or
structural biology with experience on multiple challenging protein
targets. Productive postdoctoral training and/or industry
experience is expected and should be reflected in an established
track-record of high impact publications.
Additional desired qualifications:
Hands-on experience engineering and optimizing the production of
challenging protein targets for structural and/or functional
Ability to generate and characterize milligram quantities of
high-quality protein reagents.
Proficiency in structure determination using X-ray
crystallography and/or cryo-EM is preferred.
Experience with protein engineering and/or design
Analysis, design, and/or computational approaches to investigate
Excellent communication, interpersonal, and organizational
Team-oriented and collaborative with a fearless attitude to
tackle important biological questions.