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Sr. Scientist

Company: Charles River
Location: South San Francisco
Posted on: May 3, 2021

Job Description:

Sr. Scientist

Req ID #: 105332


S. San Francisco, CA, US, 94080

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about.

Job Summary

We are seeking a highly-motivated, experienced Sr. Scientist for our growing Discovery site located in South San Francisco, CA.

The individual in this position will serve as a Scientific team member for the company. This position requires competency of all aspects of antibody studies including the skills and techniques necessary to satisfy the overall study objectives. While retaining an element of hands-on responsibility, this position is also largely focused upon leveraging the individual's scientific strengths through the mentoring and management of more junior staff.

Specific Responsibilities will include:

* Candidate will be supporting the antibody discovery group * Design and execute antibody discovery campaigns including phage display and yeast display approaches * Design and generate libraries for antibody engineering projects ranging from affinity maturation and humanization to dual-specific antibodies * Apply deep sequencing (NGS) and bioinformatics for antibody engineering * Initiate and support platform improvements * Record experiments and results, including analyzing, interpreting, and presenting data to the rest of the company * Work collaboratively on timeline-driven projects

The following are minimum requirements related to the Sr. Scientist position.

* Requirements for this position include an MS with 7+ years or PhD with 4+ years of relevant hands-on experience (preferably in industry) in biochemistry, molecular biology, protein engineering or related field * Must have experience with antibody phage display * Experience with yeast display is a plus * Must have strong expertise in wide range of molecular biology techniques including mutagenesis, molecular cloning, construct design and sequence analysis * Experience in Protein engineering techniques, including, protein expression and purification, protein interaction characterization is a plus * Experience with NGS is a plus * Detail-oriented, strong skills in organization, time management, communication and teamwork are essential. * The candidate is expected to contribute at the bench as well as at strategic levels, and present data to project teams

About Discovery

Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 13,000 employees within 80 facilities in 23 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.

At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 80% of the drugs approved by the FDA in 2017.

For more information, please visit

Equal Employment Opportunity

Charles River Laboratories, Inc. is an Equal Opportunity Employer M/F/Disabled/Vet

Nearest Major Market: San Francisco

Nearest Secondary Market: Oakland

Job Segment: Chemistry, Biochemistry, Biotech, Scientific, Scientist, Science, Engineering

Keywords: Charles River, South San Francisco , Sr. Scientist, Other , South San Francisco, California

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