Postdoctoral Fellow - Protein Analytical Chemistry
Location: South San Francisco
Posted on: May 3, 2021
We are seeking a highly talented and motivated postdoctoral
fellow to develop and establish a function-structure based approach
to better resolve and sequence chemically modified and functionally
distinct antibody variants to better identify critical quality
attributes (CQAs) of antibody drugs and targets for
multi-attributes monitoring (MAM) by LC-MS.
The selected candidate will develop and apply advanced
technologies, including established and new functional affinity
chromatography in combination with middle down and other types of
LC-MS approaches, for science-based drug development. Potential
applications include CQA assessments, function/structure linkage,
and identification of targets for MAM by LC-MS. In addition, the
candidate will be able drive their own ideas and collaborate across
Genentech and Roche Global. This work will include a strong
cross-functional collaboration with the multiple other
Pharmaceutical Technical Development (PTD), Genentech Early
Research and Development (gRED) and Roche Early Research and
Development (pRED) departments.
For information about the Postdoctoral Program at Genentech,
please go to www.gene.com/careers/academic-programs/postdocs
Who You Are
The successful candidate will be a recent PhD graduate in
Analytical Chemistry, Biochemistry, Chemical Biology, or a related
discipline. A strong publication record should provide evidence of
productive, independent contributions in science. The applicant
must have demonstrated expertise in protein characterization using
LC-MS analysis in areas such as native MS, middle down/top down MS,
post-translational modifications, and/or bottom-up MS technologies.
Prior experience with bottom up/middle down LC-MS and data analysis
with bioinformatic tools is highly desirable. Applied applications
of MS with function affinity chromatography is the most relevant
skill set, but not a requirement.
Former experience in general analytical protein chemistry, such
as protein-protein interaction technologies, protein isolation and
purification are advantageous. The successful candidate must be
highly self-motivated, capable of working independently, have
excellent oral and written communication skills, and enjoy working
in a collaborative setting.
Keywords: Genentech, South San Francisco , Postdoctoral Fellow - Protein Analytical Chemistry, Other , South San Francisco, California
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