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Postdoctoral Fellow - Protein Analytical Chemistry

Company: Genentech
Location: South San Francisco
Posted on: May 3, 2021

Job Description:

The Position

We are seeking a highly talented and motivated postdoctoral fellow to develop and establish a function-structure based approach to better resolve and sequence chemically modified and functionally distinct antibody variants to better identify critical quality attributes (CQAs) of antibody drugs and targets for multi-attributes monitoring (MAM) by LC-MS.

The selected candidate will develop and apply advanced technologies, including established and new functional affinity chromatography in combination with middle down and other types of LC-MS approaches, for science-based drug development. Potential applications include CQA assessments, function/structure linkage, and identification of targets for MAM by LC-MS. In addition, the candidate will be able drive their own ideas and collaborate across Genentech and Roche Global. This work will include a strong cross-functional collaboration with the multiple other Pharmaceutical Technical Development (PTD), Genentech Early Research and Development (gRED) and Roche Early Research and Development (pRED) departments.

For information about the Postdoctoral Program at Genentech, please go to www.gene.com/careers/academic-programs/postdocs

Who You Are

The successful candidate will be a recent PhD graduate in Analytical Chemistry, Biochemistry, Chemical Biology, or a related discipline. A strong publication record should provide evidence of productive, independent contributions in science. The applicant must have demonstrated expertise in protein characterization using LC-MS analysis in areas such as native MS, middle down/top down MS, post-translational modifications, and/or bottom-up MS technologies. Prior experience with bottom up/middle down LC-MS and data analysis with bioinformatic tools is highly desirable. Applied applications of MS with function affinity chromatography is the most relevant skill set, but not a requirement.

Former experience in general analytical protein chemistry, such as protein-protein interaction technologies, protein isolation and purification are advantageous. The successful candidate must be highly self-motivated, capable of working independently, have excellent oral and written communication skills, and enjoy working in a collaborative setting.

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Keywords: Genentech, South San Francisco , Postdoctoral Fellow - Protein Analytical Chemistry, Other , South San Francisco, California

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