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Senior Scientific Researcher, Translational Oncology

Company: Genentech
Location: South San Francisco
Posted on: May 3, 2021

Job Description:

The Department of Translational Oncology in Genentech Research is seeking a highly motivated employee to join a group of researchers evaluating novel therapies in animal tumor models. The successful candidate will perform duties consistent with a Senior Scientific Researcher, requiring proficiency with genome editing, molecular oncology and tumor signaling. The candidate will have numerous in vitro laboratory skills and familiarity with mouse in vivo and ex vivo sample analysis. The employee will develop both Genetically and Somatically Engineered Mouse Models (GEMMs and SEMMs) to evaluate the effects of experimental therapeutics alone and in combination to inform diagnostic hypotheses and clinical decision-making for experimental and clinical-stage molecules.


Applicants should have an advanced degree (MS or PhD) in molecular biology, oncology or related science. The position requires a minimum of 10 years of post-graduate hands-on relevant experience with technical expertise in multiple techniques and a track record of success as evidenced by publication record and/or evidence of sustained contributions in a biotechnology or pharmaceutical setting. Candidates must have demonstrated expertise in the design, execution and analysis of tumor animal models, pharmacokinetics/pharmacodynamics (PK/PD) studies using mouse-derived tumors and tissues ex vivo. The ideal candidate would be highly proficient in multiple analysis modalities, including multi-color flow cytometry (10+ channels), immunoblotting, RT-PCR, Fluidigm, immunofluorescence, immunohistochemistry and generation of organoids. Candidates with hands-on experience with CRISPR/Cas9 and mouse models of cancer are highly encouraged to apply. Proficiency with mouse necropsies and handling of tissue or blood or blood products for analysis is an integral component of this job. Excellent communication skills and the ability to work as part of a team are essential. Qualified candidates will have proven ability to independently design, execute and interpret experiments.

Relocation is not available for this role

Keywords: Genentech, South San Francisco , Senior Scientific Researcher, Translational Oncology, Other , South San Francisco, California

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