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Scientist, Macrocycle Discovery Group, Early Discovery Biochemistry

Company: Genentech
Location: South San Francisco
Posted on: May 3, 2021

Job Description:

An opportunity for a creative, talented and highly motivated Scientist is available in the Department of Early Discovery Biochemistry. The successful candidate will join a dynamic and cross-functional group pursuing peptide drug discovery and development, with a focus on discovering and developing macrocyclic peptides as a next-generation imaging and cell-profiling modality. This work will contribute to the development of our cutting-edge automated macrocycle discovery platform to enable the robust discovery of lead-like molecules and will require direct collaboration with diverse therapeutic functions across Genentech including Pathology, Biomedical Imaging, and Cellular and Tissue Genomics.

The successful candidate is expected to contribute to the discovery and optimization of macrocyclic peptides against targets of therapeutic interest and to characterize their mechanism of action using biochemical, biophysical, and structural biology methods. The candidate is also expected to contribute at a strategic level to support therapeutic macrocycle lead discovery programs. The candidate is expected to present their findings to project teams and senior management, as well as externally through journal publications and conference presentations.


  • Ph.D. in Biochemistry, Biophysics, Chemistry, Chemical Biology or related discipline, with at least 2 years of relevant post-doctoral or industry experience
  • Self-driven and highly motivated with a passion for discovery and innovation
  • Deep knowledge and hands-on experience with peptide chemistry, protein engineering, biophysics, structural biology, and molecular biology
  • Experience in display technologies (phage, yeast, or mRNA), small-or large-molecule screening and assay technologies, and/or optical or other imaging methods is desirable
  • Rigorous analytical and quantitative problem solving
  • Multitasking, and organizational skills, with an ability to prioritize effectively to deliver results within established timelines
  • Excellent interpersonal skills with demonstrated ability to work within a diverse team
  • Excellent mentoring skills across all levels
  • Outstanding communication skills, both orally and in writing
  • Sustained record of productivity and substantive scientific contributions as evidenced by high-impact publications, patent inventorship, and/or external presentations.


Keywords: Genentech, South San Francisco , Scientist, Macrocycle Discovery Group, Early Discovery Biochemistry, Other , South San Francisco, California

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