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Research Associate II, Protein Expression, Protein Sciences

Company: CytomX Therapeutics
Location: South San Francisco
Posted on: June 7, 2021

Job Description:

About CytomX Therapeutics:

CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel Probody therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX has a broad pipeline, including 4 clinical-stage programs and others in development and is located in South San Francisco, California, the birthplace of biotechnology. Learn more at

Location: South San Francisco, California

Reporting Relationship: Reports to the Senior Research Associate, Protein Sciences

The Opportunity:

We seek a highly motivated individual to participate in the expression and purification of protein reagents to support all discovery and development programs at CytomX. The successful candidate will work as a Research Associate II in the Protein Sciences department.

Professional Responsibilities:

  • Conduct QC testing of DNAs that goes into transfection.
  • Support the protein production by small -and large -scale transient transfection of CHO and 293 cells.
  • Develop strategies to improve the protein expression process for Probodies, various bispecific molecules and cytokines.
  • Support the purification of Probodies and various bispecific molecules.
  • Participate in molecular cloning and CHO stable cell line generation.
  • Develop analytical methods to characterize proteins.
  • Support the developability assessment of lead therapeutic molecules.
  • Manage the shipment of DNA and protein samples to CROs.


  • BS in Biochemistry or related discipline with 4+ years of experience in the biotechnology or MS in Biochemistry with 1 year of experience in the biotechnology or biopharma industry

Professional Requirements:

  • Knowledge of aseptic techniques to handle cells are required.
  • Expertise in cell culture process is highly desired.
  • Should be well versed in molecular cloning, DNA sequencing and mutagenesis.
  • Should be well versed in various transient transfection process of CHO and 293 cells.
  • Knowledge of stable cell line generation is required.
  • Experience in antibody and other protein purification techniques is required.
  • Experience in automated protein purification using Tecan liquid handlers is required.
  • Expertise in protein characterization assays such as concentration, endotoxin measurement, SDS-PAGE and SEC-HPLC is required
  • Molecular modeling experience to support developability assessment is desired.
  • Ability to support multiple projects independently is desired.
  • Excellent communication and organizational skills are required.

Personal Characteristics:

  • Demonstrate a commitment to CytomX values of Integrity, Commitment, Creativity, Teamwork, Accountability and Fun
  • Energetic, resourceful self-starter with high integrity
  • Team-player comfortable in fast-moving, dynamic environments
  • Intellectually curious, enthusiastic, creative
  • Adaptable and resilient with a problem-solving orientation
  • Innovative and flexible

CytomX is an equal opportunity employer. Employment decisions are based on merit and business needs. CytomX will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Keywords: CytomX Therapeutics, South San Francisco , Research Associate II, Protein Expression, Protein Sciences, Other , South San Francisco, California

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