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Principal Scientific Researcher, Genome Engineering, Viral Vector Technologies Group, Molecular Biology Department

Company: Genentech
Location: South San Francisco
Posted on: June 7, 2021

Job Description:

We are seeking a highly motivated, collaborative Principal Scientific Researcher (PSR) to join the Viral Vector Technologies group within Genentech's Molecular Biology Department. The candidate will develop cutting-edge technologies that enable preclinical cell and gene therapy efforts spanning a range of therapeutic areas. In addition, the PSR will build and apply gene delivery and modification technologies for in vivo functional genomics and target characterization. This includes the design, engineering, and production of AAV-based systems (capsid and cargo) with defined tropism and transgene expression control mechanisms. The candidate is expected to be nimble and eager to contribute to a fast-paced, evolving research program.


  • Ph.D. in Biochemistry, Genetics, Cell Biology, Molecular Biology, Neurobiology, Immunology, Genome Engineering, Cell/Gene Therapy, or a related field.

  • Preferably 2+ years of work experience in industry or a relevant academic setting.

  • Practical expertise with in vivo models

  • Equal ability to work independently or within a collaborative structure to advance time-sensitive projects

  • Additional expertise should include any of the following: DNA/RNA nucleases (CRISPR/Cas9), 2D and 3D cell culture, primary and/or stem cell model generation/differentiation/application, molecular cloning, epigenetics, gene network manipulation/perturbation, synthetic biology, lenti-, retro-, adeno-, AAV and other viral vector engineering/production/use. Next-Generation Sequencing (NGS), biostatistics, and/or basic bioinformatics is desirable.

The successful candidate will have demonstrated a sustained record of productivity as evidenced by high-impact publications, patents, and/or external presentations. All candidates will be expected to have excellent organizational skills, an ability to prioritize effectively, and have strong interpersonal and communication skills.

Keywords: Genentech, South San Francisco , Principal Scientific Researcher, Genome Engineering, Viral Vector Technologies Group, Molecular Biology Department, Other , South San Francisco, California

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