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Computational Scientist - R&D Assay Development

Company: Myriad Genetics & Laboratories
Location: South San Francisco
Posted on: June 8, 2021

Job Description:

Computational Scientist

San Francisco, CA (South San Francisco, California) RESEARCH & DEVELOPMENT

Our goal is to make the human genome practically useful so that it can guide life-altering decisions. We are the leader of hereditary cancer screening and prenatal screening, helping thousands of women and their families make critical healthcare decisions every day.

As a Computational Scientist at Myriad Genetics, you will build and maintain the underlying assays and analytical pipelines, working closely with molecular biologists and software engineers. Contributions include validating product updates, developing statistical analysis methods to extract robust signals from noisy experimental data, and sharing your methods in the form of simple re-usable software. The ideal candidate is detail-oriented and derives joy from bringing rigor, structure, and organization to large datasets, complex systems, and intricate analyses. We are seeking an individual who thrives in a professional atmosphere, where interdisciplinary teams are central to project success.

What you'll do

  • Make critical contributions to awesome products in a cutting-edge clinical genomics laboratory.

  • Use rigorous data science and modern software best practices to create efficient, reliable, and optimized bioinformatics pipelines.

  • Build, validate, and future-proof new products and product features that improve the lives of the patients we serve.

  • Work closely with talented molecular biologists, software engineers, automation engineers, and data scientists.

  • Characterize data resulting from novel molecular assays and guide molecular protocol development from a statistical perspective.

  • Work with legal staff to secure intellectual property rights for inventions pertaining to our products.

  • Communicate your results to stakeholders across the organization, e.g., engineering, marketing, sales, legal, and genetic counseling. You derive satisfaction from thoroughly and thoughtfully describing a system for both technical and non-technical audiences.

About you

  • Hold a PhD (or equivalent experience) in Computational Biology, Statistics, Molecular Biology, Genetics, Computer Science, Systems Biology, Biophysics, Physics, or a related discipline.

  • 3+ years experience developing methods to analyze large, noisy real-world data sets (in the context of molecular biology and/or human genetics, a plus).

  • Experience developing custom analysis methods and algorithms.

  • Strong computational skills, preferably with fluency in Python and a workflow definition language (WDL/Snakemake).

  • Knowledge of software engineering best practices (experience with writing unit-tests, performing code review, version control software, a plus).

  • Experience working with CLIA-validated assays.

  • Experience with Illumina Next Generation Sequencing (NGS)

  • Experience with other sequencing platforms such as IonTorrent, PacBio, Nanopore, a plus.

  • Experience with modern medical genetics data sets (e.g., 1000 genomes, TCGA, GIAB), a plus.

  • Working knowledge of nucleic acid chemistry and genetics, a plus

  • A sense of humility coupled with deep compassion, impeccable integrity, and an eagerness to be part of a caring and supportive team


Keywords: Myriad Genetics & Laboratories, South San Francisco , Computational Scientist - R&D Assay Development, Other , South San Francisco, California

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