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Principal/Senior Principal Scientist, Oncology Biomarker Development

Company: Hoffmann-La Roche Ltd
Location: South San Francisco
Posted on: June 8, 2021

Job Description:

We seek a highly motivated Principal pr Senior Principal Scientist to lead biomarker development efforts in support of Genentech's pipeline in hematological malignancies, specifically myeloma and lymphoma. Substantial expertise in hematology, oncology, clinical biomarkers, and translational research is highly desirable. The ideal candidate will be accomplished in deriving scientific insights and translating them into development/diagnostic opportunities. This role requires an individual with outstanding communication and leadership skills, as well as the ability to build strong relationships with key stakeholders in product development and other relevant functions, publish in high quality scientific or medical journals, and develop into a thought leader externally.

Scope of Position:

This individual will provide exceptional scientific, strategic and managerial leadership in support of a number of oncology molecules in early/late-stage clinical development and/or FDA-approved space, including leading a team of scientists. The Senior or Principal Scientist will report to the Director of Hematology in Oncology Biomarker Development (OBD) within the Development Sciences Division of Genentech Research and Early Development.

Primary Responsibilities:

  • Provide exceptional scientific leadership to peers in OBD and assigned project teams (including discovery scientists, clinical researchers, bioinformatics scientists)

  • Responsible for translating preclinical hypothesis into a clinical biomarker strategies for one or more projects

  • Have deep scientific expertise of the subject and disease to champion the translation of novel scientific discoveries into clinical development opportunities or diagnostic platforms, such as detection of minimal residual disease.

  • Provide leadership for biomarker-informed clinical development at the portfolio level for a disease area.

  • Participate and thrive in an interactive, team-oriented culture

  • Regular publication of scientific and methodological results are strongly encouraged, and scientists are expected to develop over time into externally recognized leaders in translational sciences who influence the field of personalized healthcare in oncology


  • PhD, MD or PhD/MD degree in a relevant scientific field (e.g. hematology, cancer biology, molecular biology, immunology)

  • Experience with large, multi-omic data sets and familiar with techniques for exploring associations of biomarkers with clinical outcomes.

  • Minimum of 5 years of experience in either drug discovery or drug development or relevant area of expertise for Senior Scientists. Minimum of 10 years of experience for Principal Scientist.

  • Demonstrated record of cutting-edge research as evidenced by first or senior authored publications in top tier journals; or major contributions to drug development milestones (IND filing, drug approval)

  • Be able to distill complex issues and clearly articulate solutions

  • Ability to collaborate, lead, influence and motivate others

  • Ability to demonstrate effectiveness and growth in a fast-paced and dynamic environment

  • Outstanding presentation and communication skills



Keywords: Hoffmann-La Roche Ltd, South San Francisco , Principal/Senior Principal Scientist, Oncology Biomarker Development, Other , South San Francisco, California

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