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Principal Scientific Researcher OMNI Biomarker Development (Neuroscience)

Company: Hoffmann-La Roche Ltd
Location: South San Francisco
Posted on: June 8, 2021

Job Description:


  • Identify, develop, and qualify fit-for-purpose fluid biomarker assays for neurodegenerative diseases such as Alzheimer's disease.
  • Evaluate biomarker assays in preclinical models, and optimize translatable assays for implementation in clinical trials.
  • Collaborate with scientists and scientific researchers on cross-functional and inter-departmental teams to support the development and application of clinical biomarker strategies.


  • BSc. or MSc with >5 years of experience in biotechnology or academic research environments.
  • Highly motivated, proactive, collaborative, creative, flexible, and scientifically curious.
  • Ability to independently design, execute, and troubleshoot experiments. Attention to detail.
  • Extensive experience in the development and qualification of immunoassays on a variety of platforms (e.g. ELISA, Simoa, Gyros, MSD, Singulex, Elecsys).
  • Experience working with human samples and clinical biomarkers assays is desirable. Familiarity with blood and CSF biomarkers of Alzheimer's Disease is a plus.
  • An understanding of the drug development process and previous experience with regulatory documentation such as INDs and CTAs is desired but not required
  • Strong technical skills in the laboratory, with demonstrated excellence across a spectrum of laboratory techniques such as cell culture, cytometry, SDS-PAGE/immunoblotting, and qPCR.
  • Experience with mass spectrometry is desirable but not required.
  • Capacity and desire to monitor new technologies, evaluate novel biomarker assay platforms, and learn new methodologies quickly and thoroughly.
  • Ability to independently analyze, interpret, organize, and communicate results.
  • Experience and comfort with large datasets and basic statistics. Familiar with MS Excel, MS Powerpoint, Tibco Spotfire, Graphpad Prism, and R.



Keywords: Hoffmann-La Roche Ltd, South San Francisco , Principal Scientific Researcher OMNI Biomarker Development (Neuroscience), Other , South San Francisco, California

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