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Research Associate II

Company: Adaptive Biotechnologies
Location: South San Francisco
Posted on: June 12, 2021

Job Description:

We are powering the age of immune medicine- you can too. At Adaptive, our goal is to meaningfully improve people's lives by learning from the wisdom of the adaptive immune system.

As an Adapter, you will be surrounded by driven colleagues who think boldly to pursue ground-breaking innovation. You will experience meaningful challenge in your work and be fueled by motivating energy knowing you make a difference in people's lives.

You belong here- come discover your story at Adaptive.

Position Overview

The Discovery group based in South San Francisco at Adaptive Biotechnologies is helping to identify TCR-based therapeutic candidates and clinically useful biomarkers. Our team is developing a world-class high-throughput TCR discovery platform. Our mission is to resolve the T cell repertoire by combining Adaptive's core next generation TCR sequencing with cellular immunology assays to identify antigen-specific TCRs at an unprecedented scale. Our goal is to produce clinically useful TCR-based biomarkers and therapeutics, and ultimately to map the universe of antigens recognized by human T cells.

Adaptive is seeking an accomplished, creative, and highly motivated Research Associate II to join the Discovery team in South San Francisco. You will play a key role in the design and implementation of cellular assays aimed at identifying and characterizing T cells, including assays measuring T cell antigen specificity and function.


  • Design and execute experiments with general guidance or following established protocols
  • Isolate and culture primary cells from PBMCs and perform cell-based immunological assays including assays to measure activation, proliferation, and cytokine production from T cells.
  • Culture and maintain primary cells and cell lines.
  • Work in a team and wider group to support TCR discovery-based efforts.
  • Communicate experimental results to the team and wider group.
  • Maintain laboratory instruments, reagents, consumables, and other routine laboratory tasks as needed


  • B.A./B.S./M.S. in Immunology, Cancer Biology, or related discipline with 2+ years of industry experience
  • Experience with multi-parametric flow cytometry and cell sorting


  • Experience with isolating and culturing primary immune cells for cell-based assays (T cell stimulation, proliferation, phenotyping etc.)
  • Experience with handling human tissue specimens (blood, etc.) and familiarity with BSL-2 protocols and best practices
  • Exceptional attention to detail and impeccable record-keeping skills
  • Effectively work and communicate with group members and other groups in a dynamic and fast paced environment in order to accomplish goals
  • Ability to work independently and as part of a team
  • Background knowledge of T cells, TCRs, and immunology is a plus
  • Experience in molecular biology, and NGS sequencing is a plus

Working Conditions

The individual will handle human biological specimens.

The position may require extended periods of time at the laboratory bench and the ability to lift 20 kg.

Adaptive Biotechnologies is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Equal Opportunity Employer/Veterans/Disabled

NOTE TO EMPLOYMENT AGENCIES: Adaptive Biotechnologies values our relationships with our Recruitment Partners and will only accept resumes from those partners whom have been contracted by a member of our Human Resources team to collaborate with us. Adaptive Biotechnologies is not responsible for any fees related to resumes that are unsolicited or are received by any employee of Adaptive Biotechnologies who is not a member of the Human Resources team.

Keywords: Adaptive Biotechnologies, South San Francisco , Research Associate II, Other , South San Francisco, California

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