Precision Medicine Director Obesity & Cardiometabolic Disorders

Company: Amgen
Location: South San Francisco
Posted on: November 1, 2025

Job Description:

Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Precision Medicine Director Obesity & Cardiometabolic Disorders What you will do Lets do this. Lets change the world. In this vital Director-level role, you will partner closely with Obesity and Cardiometabolic Disorders Therapeutic Area Scientists, as well as PKDM and Early Clinical Development teams. Your leadership will be essential in designing and executing translational and precision medicine strategies for early-stage assets, guiding them from Discovery through IND-enabling studies and into first-in-human (FIH) clinical trials. As a key translational thought leader, you will integrate cutting-edge scientific insights with strategic decision-making, steering the development of innovative therapies poised to redefine obesity and cardiometabolic care. You will collaborate with research project teams to identify clinically actionable biomarkers enabling: (1) Early demonstration of proof-of-concept (2) Dose determination during first-in-human studies (3) Validation and elucidation of mechanisms of action using translational datasets; and (4) Development and testing of patient-selection hypotheses in FIH trials. In collaboration with clinical teams, you will also establish reverse translational approaches, leveraging emerging clinical insights to investigate mechanisms of resistance and advance biomarker discovery. Key Responsibilities Include: Biomarker & Data Strategy: Design and lead phase-appropriate biomarker strategies (pharmacodynamics, target engagement, mechanism-of-action indicators) to support preclinical decision-making and enable FIH trials. Leverage and interpret high-dimensional datasets (e.g., genomics, proteomics, single-cell data) to refine patient-selection hypotheses and deepen understanding of target biology. Strategic Leadership in Early Development: Serve as a senior translational leader responsible for building scientifically rigorous, mechanistically informed biomarker strategies that advance preclinical assets toward clinical testing. Collaborate closely with research teams to embed biomarker, MoA, and patient-selection hypotheses early in development, providing critical data to inform key clinical decisions. Integration Across Discovery and Early Clinical Development: Act as the translational medicine bridge between research and clinical development, aligning therapeutic hypotheses, discovery data, and biomarker concepts to achieve clinical readiness and early proof-of-concept. Mechanistic and Reverse Translational Focus: Champion reverse translational strategies to investigate disease heterogeneity, mechanisms of resistance, and biomarker discovery. Establish frameworks to generate actionable hypotheses around disease biology, drug MoA, and patient subpopulations. Cross-Functional Collaboration: Partner with Discovery Research, Clinical Pharmacology, Toxicology, Early Development, and Regulatory Affairs teams to ensure seamless progression from IND-enabling activities through initiation of FIH studies. External Innovation & Partnerships: Identify and cultivate strategic collaborations with academic institutions, consortia, and biotechnology companies, incorporating innovative tools, platforms, and datasets into Amgens translational ecosystem. Maintain an influential presence as a thought leader within the external scientific community focused on obesity and cardiometabolic disorders. TA-Level Strategic Contributions: Provide scientific input into broader therapeutic area strategies, including target portfolio prioritization, endotype definition, and exploration of combination therapies grounded in human biology. Mentorship and Team Leadership: Mentor, develop, and provide strategic oversight to a team of biomarker scientists performing laboratory-based research and serving as active members on project teams. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications. Basic Qualifications: Doctorate degree and 4 years of relevant industry or academic experience, OR Masters degree and 7 years of relevant experience, OR Bachelors degree and 9 years of relevant experience. Preferred Qualifications: PhD or MD/PhD with 6 years of progressive experience in translational research within the biopharmaceutical industry, with a strong focus on metabolic or cardiometabolic diseases. Proven experience specifically in obesity research is strongly preferred. Demonstrated leadership as Project Team Lead for cardiometabolic or obesity programs, from early research stages through IND submission. Extensive experience as a biomarker lead on clinical-stage assets, with deep mechanistic expertise in obesity biology, insulin resistance, dyslipidemia, and cardiovascular pathophysiology. Recognized contributor within the scientific community through publications, presentations, or leadership roles in relevant academic or industry forums. Strong expertise in biomarker discovery and validation, multi-omics-driven stratification strategies, and patient segmentation informed by human biology. Demonstrated ability to integrate and interpret complex scientific data to support strategic development decisions, coupled with an enduring curiosity for translational science and fundamental principles of human pathophysiology. Proven ability to influence effectively in cross-functional, matrixed organizations through strong communication and leadership without direct authority. Demonstrated leadership experience managing and mentoring a team of junior Precision Medicine Scientists. What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models, including remote and hybrid work arrangements, where possible Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Keywords: Amgen, South San Francisco , Precision Medicine Director Obesity & Cardiometabolic Disorders, Science, Research & Development , South San Francisco, California