Associate Director, Toxicology
Company: Denali
Location: South San Francisco
Posted on: November 1, 2025
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Job Description:
Neurodegenerative diseases are one of the largest medical
challenges of our time. Denali Therapeutics is a biotechnology
company dedicated to developing breakthrough therapies for
neurodegenerative diseases through our deep commitment to
degeneration biology and principles of translational medicine.
Denali is founded on the collaboration of leading scientists,
industry experts, and investors who share the vision that
scientific discovery energetically applied to translational
medicine is the key to delivering effective therapies to patients.
We invite you to consider an opportunity with Denali to help
achieve our goal of delivering meaningful therapeutics to patients.
The Associate Director, Principal Scientist, Toxicology will play a
critical role in driving the nonclinical safety assessment of small
and large molecule therapeutics within Denali’s pipeline. This
position involves conducting and managing toxicology studies,
analyzing and interpreting safety data, and collaborating with
cross-functional teams to advance drug candidates through various
stages of development. This role serves as a functional leader for
the Toxicology team and includes people leadership accountability
for one or more Toxicologists. Key Accountabilities/Core Job
Responsibilities: Nonclinical Toxicology Support: Design and
implement nonclinical toxicology programs and strategies to
evaluate the safety of Denalis therapeutic candidates. Conduct and
oversee non-GLP and GLP toxicology studies, ensuring adherence to
regulatory standards. Data Analysis and Reporting: Analyze,
interpret, and summarize toxicology data to support safety
evaluations. Prepare and present safety data to internal project
teams and senior management, contributing to informed
decision-making. Regulatory Support: Assist in the preparation and
authoring of regulatory documents related to nonclinical safety
assessments. Ensure compliance with relevant regulatory guidelines
and standards throughout all stages of toxicology studies.
Collaboration and Cross-Functional Work: Work closely with
colleagues in Research and Development, providing toxicology
expertise to support cross-functional project teams. Participate in
project meetings, offering insights and recommendations to advance
safety assessment strategies. Investigative Efforts: Support
investigative efforts into mechanisms of toxicity and contribute to
the development of safer therapeutic candidates. Assist in
developing and implementing de-risking strategies for drug
discovery and development projects. People Leadership: Lead direct
report(s) through annual goal setting, growth planning, adherence
to company policies, maintain training compliance and provide
ongoing feedback on growth, development and areas of improvement.
Qualifications/Skills: PhD OR Advanced Degree in Toxicology,
Biology, Pharmacology or related scientific discipline. At or near
7 plus years of relevant work experience inclusive of postdoctoral
work; OR MS with 10 years of relevant work experience. Experience
with biologics and oligonucleotides preferred Strong scientific
background and scientific aptitude Excellent critical thinking and
scientific skills Ability to work effectively and collaboratively
on cross-functional projects teams, and demonstrated can-do
attitude Ability to work in a fast-paced environment Excellent
oral, presentation, and written communication skills Salary Range:
$203,000.00 to $240,000.00 . Compensation for the role will depend
on a number of factors, including a candidate’s qualifications,
skills, competencies, and experience. Denali offers a competitive
total rewards package, which includes a 401k, healthcare coverage,
ESPP and a broad range of other benefits. This compensation and
benefits information is based on Denali’s good faith estimate as of
the date of publication and may be modified in the future.This
compensation and benefits information is based on Denali’s good
faith estimate as of the date of publication and may be modified in
the future. Denali is committed to its core company value of unity
by creating a diverse and inclusive environment. We are proud to be
an equal opportunity employer and do not discriminate against any
employee or applicant for employment because of race, color, sex,
age, national origin, religion, sexual orientation, gender identity
and/or expression, status as a veteran, basis of disability, or any
other federal, state, or local protected class.
Keywords: Denali, South San Francisco , Associate Director, Toxicology, Science, Research & Development , South San Francisco, California
