Scientist/Senior Scientist, Analytical Development

Company: JLSa2
Location: South San Francisco
Posted on: November 3, 2025

Job Description:

JLSa2 is a new and recently launched seed-stage venture backed company, located in South San Francisco. JLSa2 is focused upon developing novel multifunctional protein-drug conjugate therapies to address human metabolic diseases and other non-oncology related diseases. The company is seeking a Scientist/Senior Scientist to develop analytical assays for these multifunctional conjugates as well as contribute to multiple aspects of product development as molecules progress from research stage to early clinical development. Responsibilities: The candidate will support the analytical development activities of novel conjugates during transition from discovery into clinical development, primarily for physicochemical assays, and will support pre-clinical formulation. The candidate will also contribute to research efforts throughout the developmental lifecycle of conjugates. The candidate will work in a highly collaborative team with the conjugation, purification, and functional assay teams, as well as senior leadership, to ensure data integration across functional areas to ensure rapid decision making and product iteration cycle time. This position is expected on site at our SSF facility. Qualifications: PhD in analytical chemistry, biochemistry, or related scientific field and 5 years of industry experience in the area of biologic conjugates is required OR BS/MS in analytical chemistry, biochemistry, or related scientific field and 10 years of industry experience in the area of biologic conjugates is required Requires a strong background in analytics of bioconjugates, such as SEC, RP-HPLC, cIEF, PAGE, with attention to detail, understanding of database systems for sample and data management is preferred. Experience with ELISA, SPR, oligonucleotides and/or peptides would be beneficial. Demonstrated proficiency in both hands-on lab work and management activities, and experience designing experiments and reviewing, organizing, and presenting data. Must have strong technical writing skills and demonstrated experience working with contract research/development organizations. Experience with IND enabling studies, regulatory filings, protein expression and purification is preferred. Demonstrated leadership ability, including a commitment to mentorship and development of personnel. Prior experience managing direct reports is preferred. Flexibility to work on multiple projects in a fast-paced start up environment is essential. Good communication skills are essential. Salary Range: $120,000 - $160,000 (Compensation and level will be commensurate with experience and expertise and could fall outside of the stated range). Competitive benefits package is offered that includes a choice of health, dental, and vision insurance, life insurance, flexible spending accounts, 401K plan, unlimited flexible time off, and early stage equity.

Keywords: JLSa2, South San Francisco , Scientist/Senior Scientist, Analytical Development, Science, Research & Development , South San Francisco, California