Senior Vice President, Early Phase Clinical Development & Clinical Operations

Company: IDEAYA Biosciences
Location: South San Francisco
Posted on: December 1, 2025

Job Description:

Non-Solicitation Policy and Notice to Agencies and Recruiters: IDEAYA's Non-Solicitation Policy strictly prohibits agencies and recruiters from any contact and communication with IDEAYA employees, managers, and leaders to submit unsolicited candidate resumes and/or to solicit business partnerships . Submission of unsolicited candidate resumes by agencies or recruiters with or without a contract in place with IDEAYA Biosciences Inc. will not create any implied obligation. Failure to comply with this policy will result in disqualification from current and future business opportunities with IDEAYA Biosciences. All recruiting and talent agency decisions are strictly managed by the internal IDEAYA Human Resources function. All communication by external agencies and recruiters must be directed to humanresources@ideayabio.com. We ask that you only email your interest once. Job Summary About IDEAYA Biosciences: IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications. Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward. For more information, please see www.ideayabio.com. Location: South San Francisco Position Summary: We are seeking a dynamic and experienced Senior Vice President of Early Phase Clinical Development & Clinical Operations to lead our Early Phase Clinical Development & Clinical Operations strategy and execution of programs. This role is responsible for setting strategy, providing medical direction, management, and review of clinical trials and product development of our early phase clinical programs. The ideal candidate will possess a deep understanding of and demonstrated track record of having successfully led early phase Oncology clinical drug development including translational science and operational excellence, while also having a solid understanding of all phases of clinical drug development. This role will manage several departments and teams including early phase clinical development, early phase clinical operations, biomarker sciences, medical writing, and project management. The successful candidate will have strong leadership skills and a track record of successful collaboration with cross-functional teams and relationship building with internal and external stakeholders. This position is based in our South San Francisco headquarter office and is required to be onsite four days per week per our company policy. This position reports to the Chief Medical Officer. Job Description What you’ll do: Oversees all early oncology development program activities and is responsible for execution of programs and timelines. Specific tasks include oversight of the strategy and design of clinical development programs for ongoing and new drug candidates, clinical protocol development, medical monitoring of clinical trials (where needed), and analysis of study data and preparation of trial reports and related regulatory documents. The individual may also serve as Development Project Leader for specific assets as the department evolves and will interact with most functions to ensure the successful progress of projects and clinical trials. Applies disease knowledge to clinical research trial development. Drives and delivers protocol development for clinical studies in collaboration with Clinical Scientists, Clinical Operations, and in close partnership with cross-functional teams Works collaboratively with associated clinical functions to oversee and participate in drafting clinical scientific documents such as IND, IND amendments, Investigator Brochures, Annual Reports (DSUR), and other FDA/HA submissions Contributes to CSR preparation and finalization In association with clinical operations colleagues and clinical scientists, contributes to the development of CRFs and data review plans when needed Oversees the Monitoring and review of safety and efficacy data in ongoing studies Serves as the key decision maker for clinical questions associated with eligibility, AE management, etc. for clinical studies Participates in developing clinical abstracts, and/or presents data at scientific meetings, SIVs, and conducts protocol training where needed Develop and participate in advisory boards Keeps abreast of hematology/oncology treatments, drug mechanism of action, approaches to drug development and regulatory requirements Acts as a clinical representative in variety of cross-functional and executive teams Partners with colleagues from Research, Translational/Biomarker and other Preclinical teams to help guide advancement of drug candidates with meaningful safety and efficacy profiles Serves as clinical partner for Business Development Ability and willingness to perform in IDEAYA’s working-leader environment where all leaders are expected to demonstrate strategic leadership, role modeling our company values, demonstrating collaboration and teamwork, and rolling up your sleeves on day-to-day deliverables Must be highly analytical, and comfortable with formulating and delivering data-driven, fact-based analysis Must be resourceful, demonstrate an agile and lean mindset approach, creative problem solver who seeks out and is receptive to new ideas and approaches to solving challenges Must fit our IDEAYA culture and be a true team player – authentic, humble, professional, and inspirational leadership skills that build a positive team spirit to galvanizes high performance Ability to adapt to changes in the work environment, industry, manages competing demands Outstanding written and verbal communication skills with the ability to effectively present to and engage with a wide range of audiences Strategic thinking with the ability to drive results in a fast-paced and dynamic environment Requirements: Medical degree and medical oncology training required Minimum of 15 years of clinical drug development experience within biopharma industry experience required Minimum of 10 years of leadership experience required Thorough understanding of oncology clinical trial design, including first-in-human Phase 1 studies of small molecules required Experience and understanding of clinical trial data monitoring and all aspects of drug development required Knowledge of GCP and ICH guidelines required Personal Strengths: A proven self-starter and team player with strong interpersonal skills who establishes & nurtures highly effective relationships with colleagues and key stakeholders to support and advance project goals and objectives Critical thinker with a solutions-oriented mindset Self-motivated to work effectively in a dynamic environment Possess strong organizational skills and conflict resolution abilities Deep experience and knowledge in oncology clinical development Total Rewards Along with our inspiring mission, and highly collaborative and inclusive environment, IDEAYA offers a competitive total rewards package that reflects our pay-for-performance philosophy where employees are eligible to be considered for merit-based salary increases, company discretionary short-term incentive plan participation, and company discretionary stock option awards (based on board approval). Our comprehensive benefits package includes, but is not limited to, medical/dental/vision coverage (100% company paid for employees and 90% company paid for dependents), 401k, ESPP, and wellness programs. The expected salary range for the roleof Senior Vice President, Early Phase Clinical Development & Clinical Operations is $399,000 - $492,000. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the office location where this open position is located, the final candidates’ experience within their profession, experience in the disease areas we are striving to make an impact in as a company, length of time within the industry, educational background, and performance during the interview process. The Company complies with all laws respecting equal employment opportunities and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite in the office at the Company’s facilities for training & meetings, with work-from-home flexibility, and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID-19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. The Company considers you fully vaccinated once 14 days have passed since you received either the second dose in a two-dose COVID-19 vaccine series or a single-dose COVID-19 vaccine. The vaccine must have been FDA approved, have emergency use authorization from the FDA, or, for persons fully vaccinated outside of the U.S., be listed for emergency use by the World Health Organization. IDEAYA is an equal opportunity employer. In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.

Keywords: IDEAYA Biosciences, South San Francisco , Senior Vice President, Early Phase Clinical Development & Clinical Operations, Science, Research & Development , South San Francisco, California